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Kansas City Chiefs vs San Francisco 49ers: Odds and Predictions

Kansas City Chiefs and San Francisco 49ers sit in opposite conferences, so a regular-season meeting comes around rarely. This page tracks the Kalshi markets for the matchup — moneyline, spread and total — alongside the meetings already played and the ones still to come.Next game: Week 16 · Sun, Dec 27, 2026
Chiefs

5

vs
49ers

0

Last 5 meetings

Next meeting

Sun, Dec 27, 2026

4:25 PM ET · NFL · Week 16

San Francisco 49ers

Kansas City Chiefs

Not listed on Kalshi yet. Markets open closer to game day.

Last meeting

Sun, Oct 20, 2024

NFL · Week 7 · 2024 season

Kansas City Chiefs

28

San Francisco 49ers

18

Head-to-head

Other Chiefs vs 49ers meetings

The rest of the games these two clubs play against each other — still to come first, then the most recent results — with the Kalshi market for any that is listed.
Sun, Feb 11, 2024 · 6:30 PM ET
San Francisco 49ers
22
Kansas City Chiefs
25
NFL Playoffs · Week 4 · 2023 season
Sun, Oct 23, 2022 · 4:25 PM ET
Kansas City Chiefs
44
San Francisco 49ers
23
NFL · Week 7 · 2022 season
Sun, Feb 2, 2020 · 6:30 PM ET
San Francisco 49ers
20
Kansas City Chiefs
31
NFL Playoffs · Week 4 · 2019 season
Sun, Sep 23, 2018 · 1:00 PM ET
San Francisco 49ers
27
Kansas City Chiefs
38
NFL · Week 3 · 2018 season
Upcoming

Next games for the Chiefs and 49ers

Every fixture either club plays next, whoever the opponent is, with the Kalshi market where one is listed.
Sun, Nov 15, 2026 · 1:00 PM ET
Kansas City Chiefs
Atlanta Falcons
NFL · Week 10
Sun, Nov 15, 2026 · 4:25 PM ET
San Francisco 49ers
Dallas Cowboys
NFL · Week 10
Sun, Nov 22, 2026 · 1:00 PM ET
Arizona Cardinals
Kansas City Chiefs
NFL · Week 11
Sun, Nov 22, 2026 · 8:20 PM ET
Minnesota Vikings
San Francisco 49ers
NFL · Week 11
Thu, Nov 26, 2026 · 8:20 PM ET
Kansas City Chiefs
Buffalo Bills
NFL · Week 12
Sun, Nov 29, 2026 · 4:25 PM ET
Seattle Seahawks
San Francisco 49ers
NFL · Week 12
Thu, Dec 3, 2026 · 8:15 PM ET
Kansas City Chiefs
Los Angeles Rams
NFL · Week 13
Sun, Dec 6, 2026 · 1:00 PM ET
San Francisco 49ers
New York Giants
NFL · Week 13
Sun, Dec 13, 2026 · 4:25 PM ET
Kansas City Chiefs
Cincinnati Bengals
NFL · Week 14
Sun, Dec 13, 2026 · 4:25 PM ET
Los Angeles Rams
San Francisco 49ers
NFL · Week 14
Recent form

Recent games for the Chiefs and 49ers

The last games each club played, whoever the opponent was — with the final score where one is available, and the market page for any that Kalshi listed.
Sun, Nov 8, 2026 · 4:05 PM ET
Las Vegas Raiders
San Francisco 49ers
NFL · Week 9
Sun, Nov 8, 2026 · 1:00 PM ET
New York Jets
Kansas City Chiefs
NFL · Week 9
Sun, Nov 1, 2026 · 4:25 PM ET
Kansas City Chiefs
Denver Broncos
NFL · Week 8
Sun, Oct 25, 2026 · 8:20 PM ET
Kansas City Chiefs
Seattle Seahawks
NFL · Week 7
Sun, Oct 25, 2026 · 1:00 PM ET
San Francisco 49ers
Atlanta Falcons
NFL · Week 7
Around the league

Other games this week

The rest of that week's league slate, without these two clubs, so the next thing to trade is one click away.
Sun, Nov 15, 2026 · 4:05 PM ET
Los Angeles Rams
Arizona Cardinals
NFL · Week 10
Sun, Nov 15, 2026 · 4:05 PM ET
Seattle Seahawks
Las Vegas Raiders
NFL · Week 10
Mon, Nov 16, 2026 · 8:15 PM ET
Los Angeles Chargers
Baltimore Ravens
NFL · Week 10
Thu, Nov 12, 2026 · 8:15 PM ET
Washington Commanders
New York Giants
NFL · Week 10
Sun, Nov 15, 2026 · 9:30 AM ET
New England Patriots
Detroit Lions
NFL · Week 10
Sun, Nov 15, 2026 · 1:00 PM ET
Buffalo Bills
New York Jets
NFL · Week 10
Sun, Nov 15, 2026 · 1:00 PM ET
Carolina Panthers
New Orleans Saints
NFL · Week 10
Sun, Nov 15, 2026 · 1:00 PM ET
Houston Texans
Cleveland Browns
NFL · Week 10
FAQ

Chiefs vs 49ers questions

When do the Chiefs and 49ers play next?
The Kansas City Chiefs and the San Francisco 49ers meet next in Week 16 in Kansas City. Kickoff times come from the NFL’s published schedule and are shown in Eastern time. A game the league flexes keeps its week while its day and time move, so it shows a date without a time until the slot is fixed.
Are the Chiefs and 49ers in the same division?
No, and not the same conference either. The Kansas City Chiefs play in the AFC West and the San Francisco 49ers in the NFC West — one an AFC club, the other NFC. That makes any meeting between them an interconference game, which the league schedules on a rotation rather than every season.
What is at stake when the Chiefs play the 49ers?
For the Chiefs and the 49ers, the overall record and only that. An interconference game touches neither club’s division record nor its conference record — but the overall record is where every seeding decision starts, and it feeds the strength-of-victory measures the league falls back on when nothing closer separates two clubs.
Can the Chiefs and 49ers meet in the playoffs?
Only in the Super Bowl. The Chiefs are in the AFC and the 49ers in the NFC, and the playoffs are run inside each conference until the final — so these two cannot be drawn against each other before it.
How often do the Chiefs and 49ers play each other?
Rarely. AFC and NFC divisions are matched in full once every four seasons, so the AFC West and the NFC West meet on that rotation. Outside it, the single interconference game each club plays against a same-position finisher can bring the Chiefs and the 49ers together sooner.
Where can I follow the Chiefs and 49ers for the rest of the season?
Each club has its own page on Kalshi. The Kansas City Chiefs and San Francisco 49ers hubs carry the roster, the weekly injury report, the remaining schedule, the division standings and the market’s read on each club’s division, playoff and Super Bowl chances.
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