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Los Angeles Chargers vs San Francisco 49ers: Odds and Predictions

Los Angeles Chargers and San Francisco 49ers sit in opposite conferences, so a regular-season meeting comes around rarely. This page tracks the Kalshi markets for the matchup — moneyline, spread and total — alongside the meetings already played and the ones still to come.Next game: Week 15 · Thu, Dec 17, 2026
Chargers

3

vs
49ers

2

Last 5 meetings

Next meeting

Thu, Dec 17, 2026

8:15 PM ET · NFL · Week 15

San Francisco 49ers

Los Angeles Chargers

Not listed on Kalshi yet. Markets open closer to game day.

Last meeting

Thu, Aug 20, 2026

NFL Preseason · Week 2

San Francisco 49ers

41

Los Angeles Chargers

17

See this game’s market on Kalshi
Head-to-head

Other Chargers vs 49ers meetings

The rest of the games these two clubs play against each other — still to come first, then the most recent results — with the Kalshi market for any that is listed.
Sun, Nov 13, 2022 · 8:20 PM ET
Los Angeles Chargers
16
San Francisco 49ers
22
NFL · Week 10 · 2022 season
Sun, Sep 30, 2018 · 4:25 PM ET
San Francisco 49ers
27
Los Angeles Chargers
29
NFL · Week 4 · 2018 season
Sat, Dec 20, 2014 · 8:25 PM ET
Los Angeles Chargers
38
San Francisco 49ers
35
NFL · Week 16 · 2014 season
Thu, Dec 16, 2010 · 8:20 PM ET
San Francisco 49ers
7
Los Angeles Chargers
34
NFL · Week 15 · 2010 season
Upcoming

Next games for the Chargers and 49ers

Every fixture either club plays next, whoever the opponent is, with the Kalshi market where one is listed.
Sun, Nov 15, 2026 · 4:25 PM ET
San Francisco 49ers
Dallas Cowboys
NFL · Week 10
Mon, Nov 16, 2026 · 8:15 PM ET
Los Angeles Chargers
Baltimore Ravens
NFL · Week 10
Sun, Nov 22, 2026 · 4:05 PM ET
New York Jets
Los Angeles Chargers
NFL · Week 11
Sun, Nov 22, 2026 · 8:20 PM ET
Minnesota Vikings
San Francisco 49ers
NFL · Week 11
Sun, Nov 29, 2026 · 4:25 PM ET
Seattle Seahawks
San Francisco 49ers
NFL · Week 12
Sun, Nov 29, 2026 · 8:20 PM ET
New England Patriots
Los Angeles Chargers
NFL · Week 12
Sun, Dec 6, 2026 · 1:00 PM ET
Los Angeles Chargers
Tampa Bay Buccaneers
NFL · Week 13
Sun, Dec 6, 2026 · 1:00 PM ET
San Francisco 49ers
New York Giants
NFL · Week 13
Sun, Dec 13, 2026 · 4:05 PM ET
Los Angeles Chargers
Las Vegas Raiders
NFL · Week 14
Sun, Dec 13, 2026 · 4:25 PM ET
Los Angeles Rams
San Francisco 49ers
NFL · Week 14
Recent form

Recent games for the Chargers and 49ers

The last games each club played, whoever the opponent was — with the final score where one is available, and the market page for any that Kalshi listed.
Sun, Nov 8, 2026 · 4:05 PM ET
Houston Texans
Los Angeles Chargers
NFL · Week 9
Sun, Nov 8, 2026 · 4:05 PM ET
Las Vegas Raiders
San Francisco 49ers
NFL · Week 9
Sun, Nov 1, 2026 · 4:05 PM ET
Los Angeles Chargers
Los Angeles Rams
NFL · Week 8
Sun, Oct 25, 2026 · 1:00 PM ET
San Francisco 49ers
Atlanta Falcons
NFL · Week 7
Mon, Oct 19, 2026 · 8:15 PM ET
Washington Commanders
San Francisco 49ers
NFL · Week 6
Around the league

Other games this week

The rest of that week's league slate, without these two clubs, so the next thing to trade is one click away.
Sun, Nov 15, 2026 · 4:05 PM ET
Los Angeles Rams
Arizona Cardinals
NFL · Week 10
Sun, Nov 15, 2026 · 4:05 PM ET
Seattle Seahawks
Las Vegas Raiders
NFL · Week 10
Sun, Nov 15, 2026 · 1:00 PM ET
Kansas City Chiefs
Atlanta Falcons
NFL · Week 10
Thu, Nov 12, 2026 · 8:15 PM ET
Washington Commanders
New York Giants
NFL · Week 10
Sun, Nov 15, 2026 · 9:30 AM ET
New England Patriots
Detroit Lions
NFL · Week 10
Sun, Nov 15, 2026 · 1:00 PM ET
Buffalo Bills
New York Jets
NFL · Week 10
Sun, Nov 15, 2026 · 1:00 PM ET
Carolina Panthers
New Orleans Saints
NFL · Week 10
Sun, Nov 15, 2026 · 1:00 PM ET
Houston Texans
Cleveland Browns
NFL · Week 10
FAQ

Chargers vs 49ers questions

When do the Chargers and 49ers play next?
The Los Angeles Chargers and the San Francisco 49ers meet next in Week 15 in Los Angeles. Kickoff times come from the NFL’s published schedule and are shown in Eastern time. A game the league flexes keeps its week while its day and time move, so it shows a date without a time until the slot is fixed.
Are the Chargers and 49ers in the same division?
No, and not the same conference either. The Los Angeles Chargers play in the AFC West and the San Francisco 49ers in the NFC West — one an AFC club, the other NFC. That makes any meeting between them an interconference game, which the league schedules on a rotation rather than every season.
What is at stake when the Chargers play the 49ers?
For the Chargers and the 49ers, the overall record and only that. An interconference game touches neither club’s division record nor its conference record — but the overall record is where every seeding decision starts, and it feeds the strength-of-victory measures the league falls back on when nothing closer separates two clubs.
Can the Chargers and 49ers meet in the playoffs?
Only in the Super Bowl. The Chargers are in the AFC and the 49ers in the NFC, and the playoffs are run inside each conference until the final — so these two cannot be drawn against each other before it.
How often do the Chargers and 49ers play each other?
Rarely. AFC and NFC divisions are matched in full once every four seasons, so the AFC West and the NFC West meet on that rotation. Outside it, the single interconference game each club plays against a same-position finisher can bring the Chargers and the 49ers together sooner.
Where can I follow the Chargers and 49ers for the rest of the season?
Each club has its own page on Kalshi. The Los Angeles Chargers and San Francisco 49ers hubs carry the roster, the weekly injury report, the remaining schedule, the division standings and the market’s read on each club’s division, playoff and Super Bowl chances.
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