Buffalo Bills vs Detroit Lions: Odds and Predictions

Buffalo Bills and Detroit Lions sit in opposite conferences, so a regular-season meeting comes around rarely. This page tracks the Kalshi markets for the matchup — moneyline, spread and total — alongside the meetings already played and the ones still to come.

Bills

5

Lions

0

Last 5 meetings

Next meeting

No other Bills vs Lions meeting is on this season's schedule.

Last meeting

Thu, Sep 17, 2026

NFL · Week 2

Detroit Lions

31

Buffalo Bills

41

See this game’s market on Kalshi

Head-to-head

Other Bills vs Lions meetings

The rest of the games these two clubs play against each other — still to come first, then the most recent results — with the Kalshi market for any that is listed.

Sun, Dec 15, 2024 · 4:25 PM ET

Buffalo Bills

48

Detroit Lions

42

NFL · Week 15 · 2024 season

Thu, Nov 24, 2022 · 12:30 PM ET

Buffalo Bills

28

Detroit Lions

25

NFL · Week 12 · 2022 season

Sun, Dec 16, 2018 · 1:00 PM ET

Detroit Lions

13

Buffalo Bills

14

NFL · Week 15 · 2018 season

Sun, Oct 5, 2014 · 1:00 PM ET

Buffalo Bills

17

Detroit Lions

14

NFL · Week 5 · 2014 season

Upcoming

Next games for the Bills and Lions

Every fixture either club plays next, whoever the opponent is, with the Kalshi market where one is listed.

Mon, Nov 9, 2026 · 8:15 PM ET

Minnesota Vikings

Sun, Nov 15, 2026 · 9:30 AM ET

New England Patriots

Sun, Nov 15, 2026 · 1:00 PM ET

Sun, Nov 22, 2026 · 1:00 PM ET

Miami Dolphins

Buffalo Bills

NFL · Week 11

Sun, Nov 22, 2026 · 1:00 PM ET

Tampa Bay Buccaneers

Detroit Lions

NFL · Week 11

Thu, Nov 26, 2026 · 1:00 PM ET

Chicago Bears

Detroit Lions

NFL · Week 12

Thu, Nov 26, 2026 · 8:20 PM ET

Kansas City Chiefs

Buffalo Bills

NFL · Week 12

Sun, Dec 6, 2026 · 1:00 PM ET

Detroit Lions

Atlanta Falcons

NFL · Week 13

Sun, Dec 6, 2026 · 4:25 PM ET

Buffalo Bills

New England Patriots

NFL · Week 13

Sun, Dec 13, 2026 · 1:00 PM ET

Tennessee Titans

Detroit Lions

NFL · Week 14

Recent form

Recent games for the Bills and Lions

The last games each club played, whoever the opponent was — with the final score where one is available, and the market page for any that Kalshi listed.

Sun, Nov 8, 2026 · 1:00 PM ET

Sun, Nov 1, 2026 · 1:00 PM ET

Baltimore Ravens

Sun, Nov 1, 2026 · 1:00 PM ET

Minnesota Vikings

Sun, Oct 25, 2026 · 4:25 PM ET

Green Bay Packers

Sun, Oct 18, 2026 · 4:25 PM ET

Las Vegas Raiders

Around the league

Other games this week

The rest of that week's league slate, without these two clubs, so the next thing to trade is one click away.

Sun, Nov 8, 2026 · 4:25 PM ET

Green Bay Packers

New England Patriots

Sun, Nov 8, 2026 · 1:00 PM ET

Kansas City Chiefs

Sun, Nov 8, 2026 · 8:20 PM ET

Tampa Bay Buccaneers

Thu, Nov 5, 2026 · 8:15 PM ET

Jacksonville Jaguars

Baltimore Ravens

Sun, Nov 8, 2026 · 9:30 AM ET

Cincinnati Bengals

Atlanta Falcons

Sun, Nov 8, 2026 · 1:00 PM ET

Cleveland Browns

New Orleans Saints

Sun, Nov 8, 2026 · 1:00 PM ET

Indianapolis Colts

Sun, Nov 8, 2026 · 1:00 PM ET

Carolina Panthers

FAQ

Bills vs Lions questions

When do the Bills and Lions play next?

The Buffalo Bills and the Detroit Lions have no meeting left in the 2026 regular season: they met once, in Week 2 in Buffalo. The Bills play next in Week 9 against the Minnesota Vikings in Minnesota, and the Lions in Week 10 against the New England Patriots at a neutral site.

Are the Bills and Lions in the same division?

No, and not the same conference either. The Buffalo Bills play in the AFC East and the Detroit Lions in the NFC North — one an AFC club, the other NFC. That makes any meeting between them an interconference game, which the league schedules on a rotation rather than every season.

What is at stake when the Bills play the Lions?

For the Bills and the Lions, the overall record and only that. An interconference game touches neither club’s division record nor its conference record — but the overall record is where every seeding decision starts, and it feeds the strength-of-victory measures the league falls back on when nothing closer separates two clubs.

Can the Bills and Lions meet in the playoffs?

Only in the Super Bowl. The Bills are in the AFC and the Lions in the NFC, and the playoffs are run inside each conference until the final — so these two cannot be drawn against each other before it.

How often do the Bills and Lions play each other?

Rarely. AFC and NFC divisions are matched in full once every four seasons, so the AFC East and the NFC North meet on that rotation. Outside it, the single interconference game each club plays against a same-position finisher can bring the Bills and the Lions together sooner.

Where can I follow the Bills and Lions for the rest of the season?

Each club has its own page on Kalshi. The Buffalo Bills and Detroit Lions hubs carry the roster, the weekly injury report, the remaining schedule, the division standings and the market’s read on each club’s division, playoff and Super Bowl chances.